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SCIENTIFIC SCORE
Possibly Effective
Based on 48 Researches
7.3
USERS' SCORE
Good
Based on 23 Reviews
8.6
Supplement Facts
Serving Size: 3 Soft Gels
Amount Per Serving
%DV
Calories
35
Total Fat
3 g
4%
Saturated Fat
0.5 g
3%
Trans Fat
0 g
†
Cholesterol
15 mg
5%
Vitamin A
30 mcg RAE
3%
Total Omega-3s
750 mg
†
EPA (Eicosapentaenoic Acid)
240 mg
†
DHA (Docosahexaenoic Acid)
360 mg
†
Other Omega-3s
150 mg
†
Top Medical Research Studies
9
Omega-3 lowers coronary risk
A Bayesian Analysis of the VITAL Trial: Effects of Omega-3 Fatty Acid Supplementation on Cardiovascular Events.
Directly related to heart disease
We explored the impact of eicosapentaenoic acid (EPA), a type of omega-3 fatty acid, on heart disease through a significant study known as the VITAL trial. This study involved nearly 26,000 older adults in the U.S. and aimed to determine the effects of daily EPA supplementation on cardiovascular events over an average follow-up of 5.3 years.
Initially, the results from VITAL seemed to show that omega-3 supplementation had no significant effect on major cardiovascular disease (CVD) events. However, by applying Bayesian methods and considering prior research in the field, we observed a more nuanced outcome. Our analysis suggested that taking EPA regularly could significantly reduce the risk of coronary heart disease events, while not showing similar benefits for stroke.
This finding supports the use of omega-3 fatty acids as a preventive measure for heart health, especially regarding coronary events. Although we didn't find evidence of a benefit for all types of cardiovascular events, the enhanced understanding gained from this reanalysis contributes valuable insights for both clinicians and patients considering omega-3 supplementation for heart disease prevention.
Initially, the results from VITAL seemed to show that omega-3 supplementation had no significant effect on major cardiovascular disease (CVD) events. However, by applying Bayesian methods and considering prior research in the field, we observed a more nuanced outcome. Our analysis suggested that taking EPA regularly could significantly reduce the risk of coronary heart disease events, while not showing similar benefits for stroke.
This finding supports the use of omega-3 fatty acids as a preventive measure for heart health, especially regarding coronary events. Although we didn't find evidence of a benefit for all types of cardiovascular events, the enhanced understanding gained from this reanalysis contributes valuable insights for both clinicians and patients considering omega-3 supplementation for heart disease prevention.
Read More
9
EPA helps fight heart disease
Eicosapentaenoic acid induces macrophage Mox polarization to prevent diabetic cardiomyopathy.
Strong evidence of EPA's benefits
We explored the effects of eicosapentaenoic acid (EPA) on heart disease, particularly diabetic cardiomyopathy (DC). This condition is a significant cause of heart failure, yet until now, effective treatment options have been limited. Our study focused on the protective role of EPA in diabetic mice induced by streptozotocin and high-fat diets.
Our findings indicate that EPA is beneficial in reducing the harmful M1-polarized macrophages in the heart. In laboratory tests, EPA showed the ability to protect heart cells from damage caused by these inflammatory cells by shifting the macrophage type from M1 to Mox, rather than to the M2 type. This is crucial since Mox polarization can help shield heart cells from the adverse effects of M1 macrophages.
Additionally, we discovered that a protein called heme oxygenase 1 (HO-1) plays a crucial role in sustaining this protective Mox phenotype. EPA promotes HO-1 levels, which in turn helps reduce M1 polarization and its damaging effects on heart cells. Even more promising, EPA was shown to enhance Mox polarization in macrophages derived from diabetic patients, indicating its potential as a treatment strategy.
Overall, our research highlights EPA and macrophage Mox polarization as innovative approaches to combat diabetic cardiomyopathy, showcasing a new avenue in the fight against heart disease.
Our findings indicate that EPA is beneficial in reducing the harmful M1-polarized macrophages in the heart. In laboratory tests, EPA showed the ability to protect heart cells from damage caused by these inflammatory cells by shifting the macrophage type from M1 to Mox, rather than to the M2 type. This is crucial since Mox polarization can help shield heart cells from the adverse effects of M1 macrophages.
Additionally, we discovered that a protein called heme oxygenase 1 (HO-1) plays a crucial role in sustaining this protective Mox phenotype. EPA promotes HO-1 levels, which in turn helps reduce M1 polarization and its damaging effects on heart cells. Even more promising, EPA was shown to enhance Mox polarization in macrophages derived from diabetic patients, indicating its potential as a treatment strategy.
Overall, our research highlights EPA and macrophage Mox polarization as innovative approaches to combat diabetic cardiomyopathy, showcasing a new avenue in the fight against heart disease.
Read More
9
Cod liver oil aids heart health
Cod liver oil supplementation improves cardiovascular and metabolic abnormalities in streptozotocin diabetic rats.
Directly addresses heart disease
We delved into how cod liver oil (CLO) influences heart health, especially in the context of diabetes. Using a study with streptozotocin (STZ)-induced diabetic rats, we treated them with CLO and monitored various cardiovascular metrics over 12 weeks. What we found was quite telling: untreated diabetic rats faced significant increases in blood sugar and harmful lipid levels, while those receiving CLO showed improved weight gain and complete prevention of lipid problems.
Moreover, the study revealed that CLO-treated rats exhibited healthier blood vessel responses and heart function. For instance, we observed that CLO effectively corrected some vasoconstriction issues and improved heart rhythm responses that were otherwise diminished in diabetic rats. The treatment also helped preserve the structural integrity of heart tissue, which often suffers in diabetes.
Overall, this research strongly suggests that cod liver oil can be a valuable supplement for mitigating heart disease risks associated with diabetes. With its rich omega-3 fatty acids and antioxidants, CLO appears to play a protective role in maintaining cardiovascular health in diabetic settings.
Moreover, the study revealed that CLO-treated rats exhibited healthier blood vessel responses and heart function. For instance, we observed that CLO effectively corrected some vasoconstriction issues and improved heart rhythm responses that were otherwise diminished in diabetic rats. The treatment also helped preserve the structural integrity of heart tissue, which often suffers in diabetes.
Overall, this research strongly suggests that cod liver oil can be a valuable supplement for mitigating heart disease risks associated with diabetes. With its rich omega-3 fatty acids and antioxidants, CLO appears to play a protective role in maintaining cardiovascular health in diabetic settings.
Read More
Most Useful Reviews
9.5
Cholesterol levels improved
I find these soft gel tablets easy to swallow with no fish taste. This product has helped regulate my cholesterol levels, supports heart health, and alleviates palpitations. My inflammation has improved, and it has thickened my hair as well. I take 2-3 capsules after breakfast daily.
Read More
9.5
Harmful cholesterol reduction
The quality of this product is high, and the ingredients are excellent. At 42, I've found the omega beneficial for my body and useful for reducing harmful cholesterol. I've noticed improvements in hair health, and it’s good for inflammation and heart health. The taste is acceptable.
Read More
9.5
Excellent health benefits
This omega is my daughter’s favourite, and it’s clearly beneficial. The quality is excellent, and it helps reduce cholesterol, fight inflammation, and supports heart and hair health. Suitable for children aged two and above, and the packaging is convenient.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 48 Researches
7.3
9
Omega-3 lowers coronary risk
A Bayesian Analysis of the VITAL Trial: Effects of Omega-3 Fatty Acid Supplementation on Cardiovascular Events.
Directly related to heart disease
We explored the impact of eicosapentaenoic acid (EPA), a type of omega-3 fatty acid, on heart disease through a significant study known as the VITAL trial. This study involved nearly 26,000 older adults in the U.S. and aimed to determine the effects of daily EPA supplementation on cardiovascular events over an average follow-up of 5.3 years.
Initially, the results from VITAL seemed to show that omega-3 supplementation had no significant effect on major cardiovascular disease (CVD) events. However, by applying Bayesian methods and considering prior research in the field, we observed a more nuanced outcome. Our analysis suggested that taking EPA regularly could significantly reduce the risk of coronary heart disease events, while not showing similar benefits for stroke.
This finding supports the use of omega-3 fatty acids as a preventive measure for heart health, especially regarding coronary events. Although we didn't find evidence of a benefit for all types of cardiovascular events, the enhanced understanding gained from this reanalysis contributes valuable insights for both clinicians and patients considering omega-3 supplementation for heart disease prevention.
Initially, the results from VITAL seemed to show that omega-3 supplementation had no significant effect on major cardiovascular disease (CVD) events. However, by applying Bayesian methods and considering prior research in the field, we observed a more nuanced outcome. Our analysis suggested that taking EPA regularly could significantly reduce the risk of coronary heart disease events, while not showing similar benefits for stroke.
This finding supports the use of omega-3 fatty acids as a preventive measure for heart health, especially regarding coronary events. Although we didn't find evidence of a benefit for all types of cardiovascular events, the enhanced understanding gained from this reanalysis contributes valuable insights for both clinicians and patients considering omega-3 supplementation for heart disease prevention.
Read More
9
Eicosapentaenoic acid improves heart function
The Optimal Dosage and Duration of ω-3 PUFA Supplementation in Heart Failure Management: Evidence from a Network Meta-Analysis.
Directly studies heart failure treatment
We explored how eicosapentaenoic acid (a type of omega-3 fatty acid) can play a role in improving heart health, particularly in individuals with heart failure. Our analysis involved a network meta-analysis of numerous randomized controlled trials, focusing on the effects of eicosapentaenoic acid on heart function.
The findings showed that high doses of omega-3 supplements, specifically between 2000 to 4000 mg per day, taken for at least a year, can significantly enhance left ventricular ejection fraction, which is an important measure of heart function. This is encouraging news for patients struggling with heart failure, as a better ejection fraction can lead to improved heart health.
We also observed improvements in peak oxygen consumption, offering further evidence of how eicosapentaenoic acid can boost cardiac performance. Importantly, we found no significant increases in dropout rates or overall mortality among those taking omega-3 supplements compared to those not taking them. This suggests that the benefits come without added risks.
Overall, our research underscores the potential of long-term, high-dose eicosapentaenoic acid supplementation as a supportive treatment option for heart failure patients, advocating for further studies to confirm these promising results and help refine treatment recommendations.
The findings showed that high doses of omega-3 supplements, specifically between 2000 to 4000 mg per day, taken for at least a year, can significantly enhance left ventricular ejection fraction, which is an important measure of heart function. This is encouraging news for patients struggling with heart failure, as a better ejection fraction can lead to improved heart health.
We also observed improvements in peak oxygen consumption, offering further evidence of how eicosapentaenoic acid can boost cardiac performance. Importantly, we found no significant increases in dropout rates or overall mortality among those taking omega-3 supplements compared to those not taking them. This suggests that the benefits come without added risks.
Overall, our research underscores the potential of long-term, high-dose eicosapentaenoic acid supplementation as a supportive treatment option for heart failure patients, advocating for further studies to confirm these promising results and help refine treatment recommendations.
Read More
9
EPA helps fight heart disease
Eicosapentaenoic acid induces macrophage Mox polarization to prevent diabetic cardiomyopathy.
Strong evidence of EPA's benefits
We explored the effects of eicosapentaenoic acid (EPA) on heart disease, particularly diabetic cardiomyopathy (DC). This condition is a significant cause of heart failure, yet until now, effective treatment options have been limited. Our study focused on the protective role of EPA in diabetic mice induced by streptozotocin and high-fat diets.
Our findings indicate that EPA is beneficial in reducing the harmful M1-polarized macrophages in the heart. In laboratory tests, EPA showed the ability to protect heart cells from damage caused by these inflammatory cells by shifting the macrophage type from M1 to Mox, rather than to the M2 type. This is crucial since Mox polarization can help shield heart cells from the adverse effects of M1 macrophages.
Additionally, we discovered that a protein called heme oxygenase 1 (HO-1) plays a crucial role in sustaining this protective Mox phenotype. EPA promotes HO-1 levels, which in turn helps reduce M1 polarization and its damaging effects on heart cells. Even more promising, EPA was shown to enhance Mox polarization in macrophages derived from diabetic patients, indicating its potential as a treatment strategy.
Overall, our research highlights EPA and macrophage Mox polarization as innovative approaches to combat diabetic cardiomyopathy, showcasing a new avenue in the fight against heart disease.
Our findings indicate that EPA is beneficial in reducing the harmful M1-polarized macrophages in the heart. In laboratory tests, EPA showed the ability to protect heart cells from damage caused by these inflammatory cells by shifting the macrophage type from M1 to Mox, rather than to the M2 type. This is crucial since Mox polarization can help shield heart cells from the adverse effects of M1 macrophages.
Additionally, we discovered that a protein called heme oxygenase 1 (HO-1) plays a crucial role in sustaining this protective Mox phenotype. EPA promotes HO-1 levels, which in turn helps reduce M1 polarization and its damaging effects on heart cells. Even more promising, EPA was shown to enhance Mox polarization in macrophages derived from diabetic patients, indicating its potential as a treatment strategy.
Overall, our research highlights EPA and macrophage Mox polarization as innovative approaches to combat diabetic cardiomyopathy, showcasing a new avenue in the fight against heart disease.
Read More
9
Omega-3s and heart disease risk
Circulating Omega-3 Polyunsaturated Fatty Acids Levels in Coronary Heart Disease: Pooled Analysis of 36 Observational Studies.
Considered broader omega-3 impacts
We explored the connection between omega-3 fatty acids, particularly eicosapentaenoic acid (EPA), and coronary heart disease (CHD). Our analysis reviewed 36 observational studies that included both prospective and retrospective designs, offering a well-rounded look at how different omega-3 levels may impact heart health.
The results highlighted a clear trend: higher levels of various omega-3 fatty acids, including EPA, were associated with a reduced risk of developing CHD. We noted that groups with elevated omega-3 levels displayed lower relative risks—indicating that maintaining a sufficient intake of these fatty acids could be beneficial for heart health.
Interestingly, our findings revealed that patients with CHD had significantly lower omega-3 levels compared to healthier individuals. Moreover, specific subtypes of omega-3, such as EPA and DHA, demonstrated a particularly strong inverse relationship with both fatal and non-fatal heart disease events.
Overall, this analysis shows that omega-3 polyunsaturated fatty acids, especially EPA and DHA, are linked to a decreased risk of CHD. Our findings support the idea that integrating these nutrients into our diets may provide protective benefits against heart disease.
The results highlighted a clear trend: higher levels of various omega-3 fatty acids, including EPA, were associated with a reduced risk of developing CHD. We noted that groups with elevated omega-3 levels displayed lower relative risks—indicating that maintaining a sufficient intake of these fatty acids could be beneficial for heart health.
Interestingly, our findings revealed that patients with CHD had significantly lower omega-3 levels compared to healthier individuals. Moreover, specific subtypes of omega-3, such as EPA and DHA, demonstrated a particularly strong inverse relationship with both fatal and non-fatal heart disease events.
Overall, this analysis shows that omega-3 polyunsaturated fatty acids, especially EPA and DHA, are linked to a decreased risk of CHD. Our findings support the idea that integrating these nutrients into our diets may provide protective benefits against heart disease.
Read More
9
Docosahexaenoic acid benefits heart health
The Optimal Dosage and Duration of ω-3 PUFA Supplementation in Heart Failure Management: Evidence from a Network Meta-Analysis.
Moderate relevance for DHA impact
We aimed to understand how docosahexaenoic acid (DHA), a form of omega-3 polyunsaturated fatty acid (PUFA), could benefit patients suffering from heart failure. Our investigation drew on a network meta-analysis that included data from 14 randomized controlled trials, comprising 9,075 participants. This analysis focused particularly on the effects of DHA and other omega-3s on heart health metrics.
The findings revealed that high doses of omega-3 PUFA supplementation, specifically between 2000 to 4000 mg daily for at least one year, significantly improved heart function. We observed notable enhancements in the left ventricular ejection fraction and peak oxygen consumption, crucial indicators of heart performance, when compared to control groups.
Interestingly, lower doses and shorter periods of supplementation did not yield the same positive results. Importantly, we found no significant increase in dropout rates or overall mortality among those taking omega-3 PUFAs compared to those who were not. This suggests that high-dose DHA supplementation can enhance cardiac function without raising safety concerns.
Overall, our research indicates that long-term, high-dose DHA can be a beneficial strategy in managing heart failure. However, we recognize that further well-designed trials with stringent criteria are needed to validate these findings fully.
The findings revealed that high doses of omega-3 PUFA supplementation, specifically between 2000 to 4000 mg daily for at least one year, significantly improved heart function. We observed notable enhancements in the left ventricular ejection fraction and peak oxygen consumption, crucial indicators of heart performance, when compared to control groups.
Interestingly, lower doses and shorter periods of supplementation did not yield the same positive results. Importantly, we found no significant increase in dropout rates or overall mortality among those taking omega-3 PUFAs compared to those who were not. This suggests that high-dose DHA supplementation can enhance cardiac function without raising safety concerns.
Overall, our research indicates that long-term, high-dose DHA can be a beneficial strategy in managing heart failure. However, we recognize that further well-designed trials with stringent criteria are needed to validate these findings fully.
Read More
User Reviews
USERS' SCORE
Good
Based on 23 Reviews
8.6
9.5
Cholesterol levels improved
I find these soft gel tablets easy to swallow with no fish taste. This product has helped regulate my cholesterol levels, supports heart health, and alleviates palpitations. My inflammation has improved, and it has thickened my hair as well. I take 2-3 capsules after breakfast daily.
9.5
Harmful cholesterol reduction
The quality of this product is high, and the ingredients are excellent. At 42, I've found the omega beneficial for my body and useful for reducing harmful cholesterol. I've noticed improvements in hair health, and it’s good for inflammation and heart health. The taste is acceptable.
Read More
9.5
Excellent health benefits
This omega is my daughter’s favourite, and it’s clearly beneficial. The quality is excellent, and it helps reduce cholesterol, fight inflammation, and supports heart and hair health. Suitable for children aged two and above, and the packaging is convenient.
9.5
Supports cholesterol level
I bought this cod liver oil for my mother, who has cholesterol issues. After three months of use and improved diet and exercise, her levels returned to normal. It reduces inflammation and heart disease. The taste is acceptable, and the quality is excellent.
9.5
Supports heart health
Heart health, brain health, and immune support are all benefits of this supplement. The lemon flavour is pleasant, and it contains 750 mg of Omega-3. It's Non-GMO, purity-tested, and doesn't leave any unpleasant fishy taste.
